| Defects in T Cell Trafficking and Resistance to Cancer Immunotherapy Softcover Repri Edition Contributor(s): Donnadieu, Emmanuel (Editor) |
|
 |
ISBN: 3319825283 ISBN-13: 9783319825281 Publisher: Springer OUR PRICE: $104.49 Product Type: Paperback - Other Formats Published: April 2018 |
| Additional Information |
| BISAC Categories: - Medical | Oncology - General - Medical | Immunology - Science | Life Sciences - Molecular Biology |
| Dewey: 611.018 |
| Series: Resistance to Targeted Anti-Cancer Therapeutics |
| Physical Information: 0.44" H x 6.14" W x 9.21" (0.66 lbs) 199 pages |
| Descriptions, Reviews, Etc. |
| Publisher Description: This volume focuses on recent advances in understanding T cells as key players in antitumor immune responses, and as a result T cell-based immunotherapy is starting to transform the treatment of advanced cancers. However, despite recent successes, many patients with cancer fail to respond to these treatments. Defective migration of T cells into and within tumors is considered as an important resistance mechanism to cancer immunotherapy.The volume includes three sections. The first section covers general knowledge about T cell trafficking during a normal immune response but also during tumor development. The second section provides an in-depth description of the different obstacles that prevent T cells from migrating and contacting tumor cells. The third section explores therapeutic strategies to improve trafficking of T cells into tumors and, thus, to enhance the effectiveness of cancer immunotherapy. |