| Inflammation and Demyelination in the Central Nervous System: International Congress of Neuropathology, Vienna, September 5-10, 1982 Contributor(s): Waksman, B. H. (Editor), Yonezawa, T. (Editor), Lassmann, H. (Editor) |
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ISBN: 3540124209 ISBN-13: 9783540124207 Publisher: Springer OUR PRICE: $104.49 Product Type: Paperback Published: August 1983 |
| Additional Information |
| BISAC Categories: - Medical | Pathology - Medical | Infectious Diseases - Medical | Diseases |
| Dewey: 616.83 |
| LCCN: 83012422 |
| Series: ACTA Neuropathologica Supplementa |
| Physical Information: 0.22" H x 6.69" W x 9.61" (0.39 lbs) 94 pages |
| Descriptions, Reviews, Etc. |
| Publisher Description: The present report, compares two murine models of virus induced chronic relapsing demyelination. MHV-induced demyelination in the BALB/c mouse results from the direct virus mediated cytolysis of oligodendrocytes. Extensive remyelination by oligodendrocytes is noted. Recurrent demyel- ination occurs in small areas. Infectious virus persists and 34 Fig. 2: Demyelination in SJL/J mice infected with TMEV. A) Multifocal areas of perivascular demyelination in the spinal cord (110 days post infection). Para- phenylene diamine stain. X 250. B) Perivascular inflammatory infiltration within the white matter of the spinal cord (22 days post infec- tion). Paraphenylene diamine stain. X600. C) Localization of TMEV associated antigen in the cytoplasm of oligodendrocytes (45 days post infec- tion). Vibratome section stained with the peroxidase-anti peroxidase technique. X 400. D) Immunoperoxidase staining of viral antigen within inner and outer loops of an oligodendrocyte (45 days post infectin) X 60,000. E) Longitudinal section showing viral antigen within Schmidt-Lanterman incisures (80 days post infection). X 49,000. viral antigens are localized within oligodendrocytes and their processes. TMEV-induced demyelination in SJL/J mice is asso- ciated with perivascular inflammatory infilrates and is dimin- ished by immunosuppressive measures. Remyelination by oligo- dendrocytes is delayed and incomplete. Chronic demyelination is widespread and associated with perivascular inflammatory infiltrates. The virus persists and viral antigen is local- ized within oligodendrocytes. |
