| Selective Estrogen Receptor Modulators: A New Brand of Multitarget Drugs 2006 Edition Contributor(s): Cano, Antonio (Editor), Calaf I. Alsina, Joacquim (Editor), Duenas-Diez, Jose Luis (Editor) |
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ISBN: 3540242279 ISBN-13: 9783540242277 Publisher: Springer OUR PRICE: $104.49 Product Type: Hardcover - Other Formats Published: June 2006 Annotation: The experience gained with tamoxifen has been the basis for the new concept of selective estrogen receptor modulators (SERMs). The action of these substances has been investigated in both basic and clinical studies, but there is not an integrated view of all the facets of this recent area in modern medicine. This book offers an up-to-date compilation of the most relevant information on the topic carried out by experienced basic and clinical investigators. The first section revises the basic determinants required to understand the functional versatility of SERMs. This part includes chapters that review the main SERM families and their principal components, the mechanisms of action of steroid hormones, SERMs and pure antiestrogens, or and the action of SERMs on the hypothalamic-pituitary unit. The second part focuses on the clinical areas where SERMs have demonstrated efficacy, such as osteoporosis, breast cancer, cardiovascular disease, and benign gynecological pathology, including actions on the endometrium, etc. There is a final chapter offering a thoughtful reflection on the role that SERMs may have in clinical practice. |
| Additional Information |
| BISAC Categories: - Medical | Gynecology & Obstetrics - Medical | Rheumatology - Medical | Endocrinology & Metabolism |
| Dewey: 616.4 |
| Physical Information: 0.96" H x 6.34" W x 9.4" (1.66 lbs) 376 pages |
| Descriptions, Reviews, Etc. |
| Publisher Description: The increasing awareness on the varied consequences of hypogonadism in distinct organs and systems has supported the notion of estrogens as systemic agents. This observation is congruent with the variety of tissues affected by - trogens when used in hormone therapy formulations on hypogonadic women. Apart from the genital tract and the breast, recognized as traditional targets for estrogens, the skeleton, the vascular tree, or the central nervous system, are good examples of territories that have demonstrated sensitivity to estrogens. This evidence has created great interest, as shown by the great amount of lit- ature that has been produced on the bene?ts and risks associated with the use of estrogens. In parallel to the clinical interest, basic research has improved our kno- edge on the complexities involved in estrogen action at the molecular level. Together with effects mediated through speci?c receptors, a concept that has been the mainstay of the interpretation of estrogen action for years, there is enough evidence to hold the notion of receptor-independent effects. The substantial advances in modern technology applied to research have helped in enlightening the particulars of this versatile action of estrogens. This more detailed knowledge on the sophisticated mechanism of action of estrogens has nourished the emergence of multiple hypotheses speculating with the p- sibility of manipulating estrogen action. The notion that a widely extended regulatory system of cell function, as it is the estrogen receptor machinery, might be modulated at wish has arisen as an attractive, although still elusive postulate. |