| Prostaglandin E1: New Aspects on Pharmacology, Metabolism and Clinical Efficacy Contributor(s): Diehm, Curt (Editor), Sinzinger, Helmut (Editor), Rogatti, Waltraud (Editor) |
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ISBN: 3540545247 ISBN-13: 9783540545248 Publisher: Springer OUR PRICE: $104.49 Product Type: Paperback Published: January 1992 |
| Additional Information |
| BISAC Categories: - Medical | Pharmacology - Medical | Immunology - Health & Fitness | Allergies |
| Dewey: 616.135 |
| LCCN: 92002138 |
| Physical Information: 0.28" H x 6.14" W x 9.21" (0.43 lbs) 117 pages |
| Descriptions, Reviews, Etc. |
| Publisher Description: Although prostaglandin El (PGE ) has been clinically available for a long 1 time, only in recent years has its effectiveness in peripheral arterial occlusive disease been confirmed in controlled studies. Not surprisingly, the favour- able results achieved both in patients with critical limb ischaemia and in those with intermittent claudication has stimulated research activities into the clinical pharmacology of this prostaglandin. As a consequence of these efforts, exciting new findings have revealed that PGE has anti thrombotic, endothelium-stabilizing and leucocyte-stabi- 1 lizing properties as well as effects on lipid metabolism, all of which, quite apart from its well-known anti-aggregating and vasodilator effects, may add to the clinical efficacy of the substance. New data have also been gathered on the metabolism of PGE most b notably the detection of 13,14-dihydro-PGE a metabolite which was b recently isolated in humans following the administration of PGE . Being 1 biologically active, the pharmacodynamic spectrum of 13,14-dihydro-PGE 1 very closely resembles that of PGE . This finding may help to explain the 1 efficacy of PGE despite its rapid metabolization when given intravenously. |