| Cell Separation: Fundamentals, Analytical and Preparative Methods 2007 Edition Contributor(s): Kumar, Ashok (Editor), Galaev, Igor Yu (Editor), Mattiasson, Bo (Editor) |
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ISBN: 3540752625 ISBN-13: 9783540752622 Publisher: Springer OUR PRICE: $208.99 Product Type: Hardcover - Other Formats Published: November 2007 |
| Additional Information |
| BISAC Categories: - Science | Biotechnology - Science | Chemistry - Analytic - Science | Life Sciences - Cell Biology |
| Dewey: 660.6 |
| LCCN: 2007935921 |
| Series: Advances in Biochemical Engineering and Biotechnology |
| Physical Information: 0.6" H x 6.1" W x 9.4" (1.10 lbs) 203 pages |
| Descriptions, Reviews, Etc. |
| Publisher Description: Cell separation, which was once limited to merely being a basic technique for fractionating different cell populations, has come a long way in the last two decades. New, advanced and more speci?c and selective techniques have emerged as the demand for isolating a speci?c cell type for various biological applications has increased. Ef?cient and cost-effective techniques for fr- tionation and isolation of target cell types are necessary to provide pure cell populations for diagnostics, biotechnological and biomedical applications. One can see a considerable need, both in biomedical research and in di- nostic medicine, for the speci?c separation of a discrete population of cells from a mixture. For example, in the ?eld of tissue engineering, isolation of stemcellsfromtissuesororgansisofparticularlygreatimportance.Moreover, understanding cell developmental pathways becomes increasingly signi?cant as diagnosis and treatment of diseases turns more to the molecular level. The diagnosis of cell-related diseases requires methods of detection, isolation and theanalysisofindividualcells, regardlessoftheirrelativecontentinthetissue. Since cell-based therapies now turn towards more realistic medical options, developing an effective separation system for large-scale cell separation has becomechallengingresearchgoalforcellbiologistsandbiotechnologists.The ideal technique should provide in a short time a good yield of cells with high puritywhile maintaining cellfunction.Despite the growingneed formethods to separate cells into cell subpopulations, the existing cell-separation te- niques stillhave somelimitations when the desired degree ofperformance on apreparativescaleisrequired.Wewillseemoreresearchfocusinthisdirection in the future. The traditional techniques of micro?ltration, ultra?ltration and ultrac- trifugation, which exploit differences in cell size, shape and density, have remainedtheworkhorsesdespitelowspeci?cityandproblemswithscalingup |
