| Long-lasting stress-induced changes in neuronal alternative splicing Contributor(s): Meshorer, Eran (Author) |
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ISBN: 3639147162 ISBN-13: 9783639147162 Publisher: VDM Verlag OUR PRICE: $50.27 Product Type: Paperback Published: April 2009 |
| Additional Information |
| BISAC Categories: - Science | Life Sciences - Biology |
| Physical Information: 0.24" H x 6" W x 9" (0.35 lbs) 100 pages |
| Descriptions, Reviews, Etc. |
| Publisher Description: Ample information suggests multileveled relationships between long-term psychological stress responses and alternative splicing - the process which yields different mRNAs from the same gene. However, the nature of these relationships remains unclear. Eran Meshorer studied the stress-induced changes in alternative splicing at Hermona Soreq's lab and shed light on the molecular pathways that lead to such responses. Meshorer focused on a particular mRNA - acetylcholinesterase (AChE), which is neuronally-expressed, stress-responsive, and yields alternatively spliced products, thus serving as an adequate model for this purpose. The book begins with an introduction covering the general areas of stress responses, their long-term consequences, the mechanism of splicing and alternative splicing, neuritic translocation of mRNAs and highlights the AChE gene and its protein products as putative mediators of such long-term consequences. The results section depicts 3 works describing 3' and 5' alternative splicing of AChE and a potential mediator of the stress-induced responses. Finally, the book ends with a discussion on the consequences of such responses, linking stress responses with aging. |