| Phylogenetic Analysis of Viral Quasispecies Contributor(s): Buendia, Patricia (Author) |
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ISBN: 3639452275 ISBN-13: 9783639452273 Publisher: AV Akademikerverlag OUR PRICE: $81.05 Product Type: Paperback - Other Formats Published: August 2012 |
| Additional Information |
| BISAC Categories: - Medical | Microbiology - Science | Life Sciences - Microbiology - Science | Life Sciences - Biology |
| Dewey: 616 |
| Physical Information: 0.48" H x 6" W x 9" (0.69 lbs) 208 pages |
| Descriptions, Reviews, Etc. |
| Publisher Description: Revision with unchanged content. A new approach in the analysis of viral evolution is presented in this book, an approach that merges Phylogenetic analysis and Bioinformatic techniques. Patterns of viral evolution are inferred from serially-sampled sequence data, i.e., sequence data obtained from strains isolated at consecutive time points from a single patient or host. Traditional phylogenetic methods assume a tree-like evolutionary model, while many RNA viruses have the capacity to exchange genetic material with one another using a process called re-combination. A genealogy involving recombination is best described by a net-work structure. A more general approach was implemented in a new compu-tational tool, Sliding MinPD, one that is mindful of the sampling times of the input sequences and that reconstructs the viral evolutionary relationships in the form of a network structure with implicit representations of recombi-nation events. The underlying network organization reveals unique patterns of viral evolution and could help explain the emergence of disease-associated mutants and drug-resistant strains, with implications for patient prognosis and treatment strategies. |