| Current Topics in Microbiology and Immunology / Ergebnisse Der Mikrobiologie Und Immunitätsforschung: Volume 62 Softcover Repri Edition Contributor(s): Arber, W. (Author), Haas, R. (Author), Henle, W. (Author) |
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ISBN: 3642657745 ISBN-13: 9783642657740 Publisher: Springer OUR PRICE: $104.49 Product Type: Paperback - Other Formats Published: December 2011 |
| Additional Information |
| BISAC Categories: - Medical | Immunology - Science | Life Sciences - Microbiology - Science | Life Sciences - Biology |
| Dewey: 579 |
| Series: Current Topics in Microbiology and Immmunology |
| Physical Information: 0.39" H x 6.69" W x 9.61" (0.67 lbs) 176 pages |
| Descriptions, Reviews, Etc. |
| Publisher Description: General aspects of nucleic acid uptake by mammalian cells have been the subject of several reviews during the last few years (PAGANO, 1970; BHARGAVA and SHANMUGAM, 1971; DUBES, 1971; RYSER, 1967). These reviews covered methods used for the infection of cells by viral nucleic acids as well as interaction of mammalian cells with non-viral nucleic acids. This article is restricted to a discussion of experiments with poliovirus RNA and focuses special attention on the steps following the uptake of RNA into a cell, aspects that were not discussed in earlier review articles. The fate of input RNA once inside the cell is determined by the host cell but experimental conditions can be chosen to favor the survival of input RNA and the induction of a virus growth cycle by interfering with host-cell meta- bolism through events that, in the case of infection with intact virus, might be controlled by viral proteins. |
