| Human T-Cell Leukemia Virus Softcover Repri Edition Contributor(s): Vogt, P. K. (Editor) |
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ISBN: 3642701159 ISBN-13: 9783642701153 Publisher: Springer OUR PRICE: $104.49 Product Type: Paperback - Other Formats Published: December 2011 |
| Additional Information |
| BISAC Categories: - Medical | Microbiology - Medical | Infectious Diseases - Medical | Oncology - General |
| Dewey: 616.994 |
| Series: Current Topics in Microbiology and Immmunology |
| Physical Information: 0.59" H x 6.69" W x 9.61" (1.00 lbs) 266 pages |
| Descriptions, Reviews, Etc. |
| Publisher Description: characteristic features in common with the genome of other retroviruses: long terminal repeats (L TR), and coding regions for internal proteins (gag), for re- verse transcriptase (pol), and for glycosylated virion surface proteins (env), ar- ranged in the sequence gag, pol, env from the 5' to the 3' end of the genome. However, the HTL V genome also contains some specific features not shared with all other retroviruses: the LTR regions are unusually long (745 base pairs, with 298 base pairs constituting the R region), but unlike the long L TRs of mouse mammary tumor viruses, they do not contain open reading frames. A stretch of noncoding sequences separates the gag and the pol genes. Most interestingly, the HTLV genome contains a region between the 3' end of the env gene and the L TR, called the pX region, that encompasses four open reading frames. Leukemic T cells freshly obtained from patients contain the HTL V provirus but usually do not express it. However, once established in culture, these cells produce viral proteins and release type C particles. Likewise, T cells infected and transformed by HTL V in vitro synthesize virus. Such producing cell lines have been widely used in seroepidemiological surveys and continue to be of importance for detailed studies of viral proteins and nucleic acids. |