| Molecular Aspects of Oxidative Drug Metabolizing Enzymes: Their Significance in Environmental Toxicology, Chemical Carcinogenesis and Health Softcover Repri Edition Contributor(s): Arinc, Emel (Editor), Schenkman, John B. (Editor), Hodgson, Ernest (Editor) |
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ISBN: 3642795307 ISBN-13: 9783642795305 Publisher: Springer OUR PRICE: $104.49 Product Type: Paperback - Other Formats Published: December 2011 |
| Additional Information |
| BISAC Categories: - Medical | Toxicology - Science | Life Sciences - Biochemistry - Medical | Pharmacology |
| Dewey: 615.95 |
| Series: NATO Asi Subseries H: |
| Physical Information: 1.28" H x 6.14" W x 9.21" (1.93 lbs) 614 pages |
| Descriptions, Reviews, Etc. |
| Publisher Description: Presented here are recent advances in biochemical, toxicological, and regulatory aspects of oxidative drug metabolizing enzymes. Mainly cytochrome P450-dependent and flavin-containing monooxygenases (FMO) are covered. Moreover, the book deals with genotoxicity studies and toxicological interactions of environmental chemicals and mechanisms of mutagenicity and tumor formation. The construction of genetically engineered mammalian cells for the production of a specific P450 isozyme and the application of these cell lines in drug metabolism, mutagenicity and toxicity studies are described in detail. Further, insight is provided into how a number of aquatic species cope with pollutants and their genotoxicity. |
