| Toxicity studies of Norfloxacin, a fluoroquinolone in rats Contributor(s): R. Rashmi (Author), Sanganal Jagadeesh (Author), N. B. Shridhar (Author) |
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ISBN: 3659612014 ISBN-13: 9783659612015 Publisher: LAP Lambert Academic Publishing OUR PRICE: $63.51 Product Type: Paperback Published: October 2014 |
| Additional Information |
| BISAC Categories: - Medical | Veterinary Medicine - General |
| Physical Information: 0.32" H x 6" W x 9" (0.46 lbs) 136 pages |
| Descriptions, Reviews, Etc. |
| Publisher Description: In acute oral toxicity LD50 value obtained was 4541.1067 mg/ kg. In repeated dose 28 day subacute oral toxicity study, hematological parameters viz., TEC, Hb, Hct and TLC showed significant decreased level in treated groups. Similarly biochemical parameters viz., aspartate aminotransferase, alanine aminotransferase, BUN, creatinine showed significant increased level in treated groups. There was a significant decrease in body weight gain in treated groups. Satellite high dose group animals showed partial recovery in terms of haematological, biochemical parameters and body weight gain after cessation of norfloxacin administration. Histopathology of both male and female rats revealed toxic effect of norfloxacin on liver, kidney, heart, spleen and intestines. Satellite high dose group showed recovery to normalcy in histopathological study. |
