| Yadernye Retseptory Ppar V Regulyatsii Vospalitel'nykh Protsessov Mozga Contributor(s): Alyeshin Stepan (Author), Sergeeva Marina (Author) |
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ISBN: 384330095X ISBN-13: 9783843300957 Publisher: LAP Lambert Academic Publishing OUR PRICE: $60.53 Product Type: Paperback Language: Russian Published: October 2010 |
| Additional Information |
| BISAC Categories: - Science | Life Sciences - Biology |
| Physical Information: 0.36" H x 6" W x 9" (0.52 lbs) 156 pages |
| Descriptions, Reviews, Etc. |
| Publisher Description: V monografii rassmotreny molekulyarnye mekhanizmy uchastiya yadernykh retseptorov PPAR (retseptory aktivatorov proliferatsii peroksisom) v regulyatsii vospalitel'nykh protsessov. PPAR reguliruyut transkriptsiyu bolee 1000 genov, uchastvuyushchikh v regulyatsii vrozhdennogo immuniteta, lipidnogo i uglevodnogo gomeostaza. Sinteticheskie ligandy PPAR - gipolipidemicheskie i gipoglikemicheskie lekarstva: roziglitazon, fenofibrat, bezafibrat i dr. Narushenie funktsiy PPAR nablyudaetsya pri ozhirenii, diabete 2 tipa, serdechno-sosudistykh i neyrodegenerativnykh zabolevaniyakh. Effektivnost' primeneniya ligandov PPAR dlya lecheniya insul'ta, travm mozga, bolezney Al'tsgeymera i Parkinsona pokazana na zhivotnykh. Avtorami provedeno eksperimental'noe issledovanie vzaimosvyazi tryekh izotipov retseptorov PPARα, -β, -γ pri aktivatsii kletok glii. Opisan mekhanizm vzaimodeystviya izotipov v regulyatsii tsiklooksigenazy 2 i fosfolipaz A2, fermentov sinteza prostaglandinov i vyshchepleniya iz fosfolipidov ω-6/ ω-3 zhirnykh kislot. Eti veshchestva yavlyayutsya endogennymi ligandami PPAR i mediatorami vospaleniya. Obsuzhdaetsya vozmozhnost' ispol'zovaniya dvoynykh agonistov i ingibitorov sinteza prostaglandinov dlya regulyatsii dinamiki vospalitel'nogo protsessa. |
