| Survey of active pharmaceutical ingredients-excipient incompatibility Contributor(s): Shunmugaperumal, Tamilvanan (Author) |
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ISBN: 3843364931 ISBN-13: 9783843364935 Publisher: LAP Lambert Academic Publishing OUR PRICE: $50.27 Product Type: Paperback Published: October 2010 |
| Additional Information |
| BISAC Categories: - Medical | Pharmacology |
| Physical Information: 0.28" H x 6" W x 9" (0.41 lbs) 120 pages |
| Descriptions, Reviews, Etc. |
| Publisher Description: To improve physico-chemical properties of an active pharmaceutical ingredient (API) at its preformulation stage, myriad of excipients having defined functional roles like solubility enhancement by co-solvent, micells formation and complexation, intestinal permeability enhancement through the inhibition of efflux transport mechanisms, stability-improvement using pH adjustment, cryo-and lyo-protectants, etc are incorporated into a dosage form containing the API. Although considered primarily as inactive materials, the excipient(s) may react with the API resulting in the development of a detrimental or beneficial substance within the API-loaded dosage form itself. If detrimental substances are formed, then, the issue of API-excipient incompatibility will come up and demand the reformulation of the API, which is costly and time-consuming. This book surveys a comprehensive list of published examples of API-excipient incompatibility relevant to currently or previously marketed drugs. With this coverage, this book also provides first-hand information on the multicomponent nature and complexity of the excipients to the formulation scientist. |