| Nephrotoxic Effects of Insecticide Diazinon Contributor(s): Shah, Muhammad Dawood (Author), Iqbal, Mohammad (Author), J. a. D'Souza, Urban (Author) |
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ISBN: 3846502375 ISBN-13: 9783846502372 Publisher: LAP Lambert Academic Publishing OUR PRICE: $60.53 Product Type: Paperback Published: October 2011 |
| Additional Information |
| BISAC Categories: - Science | Life Sciences - Biochemistry |
| Physical Information: 0.37" H x 6" W x 9" (0.54 lbs) 160 pages |
| Descriptions, Reviews, Etc. |
| Publisher Description: Diazinon (O, O-diethyl-O-[2-isopropyl-6-methyl-4-pyrimidinyl] phosphoro thioate), an organo-phosphate insecticide, has been used worldwide in agriculture and domestic for several years, which has led to a variety of negative effects in non target species including humans. However, its nephrotoxic effects and mechanism of action has not been fully elucidated so far. Therefore, the present study was aimed at evaluating the nephrotoxic effects of diazinon and its mechanism of action with special reference to its possible ROS generating potential in rats. Treatment of rats with diazinon significantly enhances renal lipid peroxidation which is accompanied by a decrease in the activities of renal antioxidant enzymes (e.g. catalase, glutathione peroxidise, glutathione reductase, glucose-6-phosphate dehydrogenase, glutathione S-transferase) and depletion in the level of glutathione reduced. In contrast, the activities of renal -glutamyl transpeptidase and quinone reductase were increased. Parallel to these changes, diazinon treatment enhances renal damage as evidenced by sharp increase in blood urea nitrogen and serum creatinine |