| Nanocarrier Systems for Drug Delivery for the Treatment of Asthma Contributor(s): Elhissi, Abdelbary (Author), Taylor, Kevin (Author), Ahmed, Waqar (Author) |
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ISBN: 3846532614 ISBN-13: 9783846532614 Publisher: LAP Lambert Academic Publishing OUR PRICE: $81.05 Product Type: Paperback Published: October 2011 |
| Additional Information |
| BISAC Categories: - Medical |
| Physical Information: 0.58" H x 6" W x 9" (0.84 lbs) 256 pages |
| Descriptions, Reviews, Etc. |
| Publisher Description: This book presents work on nanocarrier systems for pulmonary drug delivery for use in the treatment of asthma. Using sucrose as a carrier, liposomes were generated or dispersed in situ from proliposomes within the medical nebulisers investigated. The Pari (air-jet) and the Omron (vibrating-mesh) nebulisers produced large mass and lipid outputs with a large lipid fraction deposited in the lower stage of a two-stage impinger. The Liberty (Ultrasonic) nebuliser failed to deliver more than 6% of the lipid employed.Multilamellar liposomes were generated from ethanol-based proliposomes. The resultant vesicles entrapped 62% of the available salbutamol sulphate compared to only 1.23% entrapped by liposomes made by the thin film method. Aeroneb Pro or Aeroneb Go vibrating-mesh nebulisers generated aerosol droplets of larger volume median diameter and narrower size distribution than the Pari (air-jet) nebuliser. Unlike the vibrating-mesh nebulisers, the performance of the jet nebuliser was independent of formulation. A nebuliser-dependent significant loss of the originally entrapped drug was demonstrated. A customised large mesh Aeroneb Pro reduced the drug losses during nebulisation. |