| Design, Synthesis and Pharmacological Screening of 1,4-Diazepines Contributor(s): Bapat, Bhushan (Author), Shah, Vishal (Author) |
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ISBN: 3848489368 ISBN-13: 9783848489367 Publisher: LAP Lambert Academic Publishing OUR PRICE: $60.53 Product Type: Paperback Published: May 2012 |
| Additional Information |
| BISAC Categories: - Medical | Pharmacology |
| Physical Information: 0.33" H x 6" W x 9" (0.47 lbs) 140 pages |
| Descriptions, Reviews, Etc. |
| Publisher Description: Diazepines are pharmaceutically important compounds owing to their Central Nervous System Depressant activity. Among these 1,4-diazepines are regarded as privileged structures due to their clinical importance & commercial success. The immense work has been carried out on Diazepine nucleus. Investigators have followed variable routes for the synthesis, mostly 1,2-diamines are implemented as reagents using a catalyst that allows cyclization. Wide range of Biological activities exhibited by diazepines has attracted many workers to screen the analogues for all possible activities. Present book covers base catalyzed condensation reaction of 1, 2-diamines with carbonyl compounds, an efficient method for the synthesis of fused 1,4-diazepines. Synthesized compounds were characterized and screened for Cytotoxic, Anti-Microbial and Anti-convulsant Activities. |