| Early Indicators Early Treatments Neuroprotection in Multiple Sclerosis 2004 Edition Contributor(s): Hommes, O. R. (Author), Comi, G. (Author) |
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ISBN: 8847001951 ISBN-13: 9788847001954 Publisher: Springer OUR PRICE: $104.49 Product Type: Hardcover - Other Formats Published: February 2004 Annotation: This book reviews the main neurobiological, neurophysiological, MRI and clinical features of the early phases of MS. Mechanisms of irreversible axonal damage and the role played by the interaction between glial and axons are highlighted. Contrary to what was thought for a long time the sufficient availability of oligodendrocyte precursor cells to promote remyelination in acute lesions has now been demonstrated. For not understood reasons, remyelination process fails or does not start in many cases, particularly, in the chronic process of the disease. These findings express the importance of the milieu changes induced by inflammatory process in limiting remyelination. Pathological studies demonstrate that in MS destructive processes may be followed by recovering phases in such a way that myelin may be morphologically and functionally reconstructed. This all brings the rationale of early treatments and the results of clinical trials in early MS to the fore as one of the most important questions today. |
| Additional Information |
| BISAC Categories: - Medical | Neurology - Medical | Radiology, Radiotherapy & Nuclear Medicine |
| Dewey: 616.834 |
| LCCN: 2003065478 |
| Series: Topics in Neuroscience |
| Physical Information: 0.88" H x 6.36" W x 9.54" (1.20 lbs) 199 pages |
| Descriptions, Reviews, Etc. |
| Publisher Description: There is now evidence that irreversible brain damage accumulates very early in the course of multiple sclerosis. This book reviews the main neurobiological, magnetic resonance imaging, and clinical aspects of the early phases of the dis- ease. Mechanisms ofirreversible axonal damage and the role played by the inter- action of glia and the axon are highlighted. In contrast to what was believed for a long time, the sufficient availability of oligodendrocyte precursor cells to promote remyelination in acute lesions has now been demonstrated. For reasons not understood, this remyelination process fails or does not start, particularly in the chronic stages ofthe disease. These findings emphasize the importance of the "milieu" changes induced by an inflammatory process in limiting remyelination. However, first indications are that part of this inflammatory process may have a neuroprotective effect. Pathological studies in multiple sclerosis have now clearly demonstrated that destructive processes may be followed by recovery phases in such a way that myelin may be morphologically and functionally reconstituted. These findings provide the rationale for early treatment and emphasize the importance of clinical trials in early multiple sclerosis. Early treatment is one of the most important aspects in multiple sclerosis today. |
