| Total Synthesis of Natural Products with Antimicrobial Activity Softcover Repri Edition Contributor(s): Giltrap, Andrew (Author) |
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ISBN: 9811342458 ISBN-13: 9789811342455 Publisher: Springer OUR PRICE: $132.99 Product Type: Paperback - Other Formats Published: February 2019 |
| Additional Information |
| BISAC Categories: - Science | Chemistry - Clinical - Medical | Biochemistry - Medical | Pharmacology |
| Dewey: 612.015 |
| Series: Springer Theses |
| Physical Information: 0.62" H x 6.14" W x 9.21" (0.91 lbs) 268 pages |
| Descriptions, Reviews, Etc. |
| Publisher Description: This thesis focuses on the development of efficient and scalable total syntheses of natural products that can be used as preferred scaffolds for anti-infective drug discovery. It describes the total synthesis of two classes of antimicrobial non-ribosomal peptides (NRPs) - teixobactin and the skyllamycins - with subsequent biological evaluation. The first part describes the first total synthesis of teixobactin by means of a solid-phase peptide synthesis-macrolactamisation approach, yielding a synthetic natural product that can combat a number of clinically relevant Gram-positive bacterial pathogens. The second part describes the first total synthesis of skyllamycins A-C, a family of structurally complex cyclic NRPs, which inhibit the growth of the Pseudomonas aeruginosa biofilms that are responsible for significant mortality among cystic fibrosis patients. |