| Actin Polymerization in Apicomplexan: A Structural, Functional and Evolutionary Analysis 2019 Edition Contributor(s): Kale, Avinash (Editor) |
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ISBN: 981137452X ISBN-13: 9789811374524 Publisher: Springer OUR PRICE: $104.49 Product Type: Paperback - Other Formats Published: November 2020 |
| Additional Information |
| BISAC Categories: - Medical | Parasitology - Sports & Recreation - Science | Life Sciences - Biochemistry |
| Dewey: 570.285 |
| Physical Information: 101 pages |
| Descriptions, Reviews, Etc. |
| Publisher Description: This book discusses in detail the structural, evolutionary and functional role of actin and its regulatory proteins in gliding motility in apicomplexan organisms, a unique phenomenon found in actin-myosin cytoskeletal elements. The book also explores the potential of different actin regulators, namely formin, profilin, actin depolymerization factor (ADF), capping proteins (CPα and CPβ), cyclase-associated protein (CAP) and coronin 13-24 as potential drug targets against malaria. As the chief components of the gliding motor, the actin-regulator proteins are characterized by unique features that make them promising targets for structure-based drug design. Lastly, the book proposes a mathematical model, based on kinetic data mining, to help understand the most vital regulators for actin polymerization dynamics. |