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FROM EMPTINESS TO HAPPINESS, Anaesthetising Negative Emotions is the story of a fiercely independent, young Anaesthesiologist Dr Riya. Riya is an emotional person; every emotion she experiences is deep and intense. After a tragic incident she relocates to Mangalore to start afresh. Riya meets Dr Samith a general surgeon in the operating room and develops an instant liking for him.

She discovers that they have a common friend, someone who played an important role in her life before relocating to Mangalore, someone she never wanted to remember. Samith is a simple guy from a conservative family. Even though Samith didn't approve of Riya's past, he loved having her around. Riya had mental health issues to deal with, she had to gain control over her intense emotions and get her life back on track. She is aware that history could repeat and there could be fatal ramifications if things didn't end well with Samith. She decides to give it a chance as her gut feeling told her that Samith loved her. Will they end up together? Will history repeat? Let us find out.