| Metabolic engineering of Basfia succiniciproducens for the production of carbon-three compounds (Band 7) Contributor(s): Fabarius, Jonathan Thomas (Author) |
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ISBN: 3736999135 ISBN-13: 9783736999138 Publisher: Cuvillier OUR PRICE: $49.69 Product Type: Paperback Published: December 2018 |
| Additional Information |
| BISAC Categories: - Medical | Microbiology |
| Physical Information: 0.31" H x 5.83" W x 8.27" (0.40 lbs) 144 pages |
| Descriptions, Reviews, Etc. |
| Publisher Description: Beschreibung The recent rise of bio-succinic acid as an industrial platform chemical has brought the rumen bacterium Basfia succiniciproducens, a natural producer of this organic acid, into the focus of research. This work investigated the potential of B. succiniciproducens for the production of carbon-three chemicals from sugars. Beside the optimization of improved genetic tools, the C3 chemicals alanine, β-alanine and 3-hydroxypropionate (3-HP) were targeted. A new alanine producer, B. succiniciproducens ALA-1, exhibited good performance in the bioprocess. The next step demonstrated the proof-of-concept for β-alanine synthesis using the heterologous expression of aspartate 1 decarboxylase genes from Corynebacterium glutamicum or Vibrio natriegens. The expression of two additional genes enabled the de novo synthesis of up to 100 mg L-1 3-HP from glucose. |
