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This volume presents theoretical and empirical research on universities and their entrepreneurial ecosystems to better grasp the connections between universities and their surrounding environments and their engagement with sustainability. The book provides a better understanding of the entrepreneurial characteristics of universities. It examines the ways in which universities' collaboration and participation in an ecosystem support business and industry transformation. It also investigates how universities function within the university/industry/government/third sector relationship nexus. The book enables the systematisation of the literature while simultaneously builds theory, empirically testing existing theories, and contributes towards a future research agenda geared towards sustainability. The book gathers contributions from varied geographical contexts providing an international perspective.