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For years, drug overdose was unmentionable in polite society. OD was understood to be something that took place in dark alleys--an ugly death awaiting social deviants--neither scientifically nor clinically interesting. But over the last several years, overdose prevention has become the unlikely object of a social movement, powered by the miracle drug naloxone. In OD, Nancy Campbell charts the emergence of naloxone as a technological fix for overdose and describes the remaking of overdose into an experience recognized as common, predictable, patterned--and, above all, preventable. Naloxone, which made resuscitation, rescue, and "reversal" after an overdose possible, became a tool for shifting law, policy, clinical medicine, and science toward harm reduction. Liberated from emergency room protocols and distributed in take-home kits to non-medical professionals, it also became a tool of empowerment.

After recounting the prehistory of naloxone--the early treatment of OD as a problem of poisoning, the development of nalorphine (naloxone's predecessor), the idea of "reanimatology"--Campbell describes how naloxone emerged as a tool of harm reduction. She reports on naloxone use in far-flung locations that include post-Thatcherite Britain, rural New Mexico, and cities and towns in Massachusetts. Drawing on interviews with approximately sixty advocates, drug users, former users, friends, families, witnesses, clinicians, and scientists--whom she calls the "protagonists" of her story--Campbell tells a story of saving lives amid the complex, difficult conditions of an unfolding unnatural disaster.