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Protein Misfolding in Neurodegenerative Diseases: Mechanisms and Therapeutic Strategies
Contributor(s): Sewell, Robert D. E. (Editor)
ISBN: 036738812X     ISBN-13: 9780367388126
Publisher: CRC Press
OUR PRICE:   $75.95  
Product Type: Paperback - Other Formats
Published: October 2019
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Additional Information
BISAC Categories:
- Science | Chemistry - General
- Medical | Neurology
- Medical | Biochemistry
Dewey: 616.804
Series: Enzyme Inhibitors
Physical Information: 1" H x 6.1" W x 9.3" (2.15 lbs) 596 pages
 
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Research focused on protein folding, misfolding, and aggregation is leading to major advances across biochemistry and medicine. The elucidation of a folding code is proving to be of extreme importance in the postgenomic era, where a number of orphan genes have been identified for which no clear function has yet been established. This research is starting to shed light on the molecular and biochemical basis of a number of neurodegenerative diseases of dramatic impact.

Protein Misfolding in Neurodegenerative Diseases: Mechanisms and Therapeutic Strategies addresses key issues concerning protein misfolding and aggregation in neurodegenerative diseases. Building on recent developments, including the recognition of protein misfolding as both a marker and a causal agent, the text presents the work of those who are actively pursuing more effective treatments, as well as preventative measures, and a possible cure. These include the use of molecular chaperones to control misfolding and novel pharmaceuticals, as well as the potential role of various inhibitors and NSAIDS.

A Comprehensive Multifaceted Examination of the Complex Causal Agents Implicated in Protein Misfolding

Divided into five sections, this groundbreaking text provides up-to-date accounts for Alzheimer's, Parkinson's, Huntington's, Amyotrophic Lateral Sclerosis and Transmissible Spongiform Encephalitis. It also explores the highly likelihood that multiple factors, including oxidative stress, play a role in these complex diseases.