Interleukin-27: Biological Properties and Clinical Application 2016 Edition Contributor(s): Jankowski, Marek (Author), Wandtke, Tomasz (Author), Jakubowska, Marta (Illustrator) |
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ISBN: 3319396625 ISBN-13: 9783319396620 Publisher: Springer OUR PRICE: $52.24 Product Type: Paperback Published: May 2016 |
Additional Information |
BISAC Categories: - Medical | Immunology - Science | Life Sciences - Biochemistry |
Dewey: 572.6 |
Series: Springerbriefs in Immunology |
Physical Information: 0.19" H x 6.14" W x 9.21" (0.32 lbs) 86 pages |
Descriptions, Reviews, Etc. |
Publisher Description: This volume focuses on various aspects of interleukin-27 (IL-27), especially its potential for clinical applications. The authors discuss the downstream signaling from the IL-27 receptor and its molecular targets in immune cells including Th1, Th2, Th17, Treg, Tr1, Tfh, B cells, DCs and macrophages. The inhibition of Th17 cells by IL-27 is vital for the maintenance of the feto-maternal tolerance and the prevention of lupus, multiple sclerosis, autoimmune uveitis, immune thrombocytopenia and atherosclerosis. However, the same inhibitory capabilities compromise the immune response to bacterial pathogens, and IL-27 is a pathogenic factor in sepsis and tuberculosis. Also covered are the conflicting reports on the role of IL-27 in rheumatoid arthritis, the effect of IL-27 on epithelia, which seems to play a role in asthma, psoriasis and inflammatory bowel diseases, and the direct cytotoxic and anti-vascular effects of IL-27, which make it a promising agent for the treatment of cancer. Accordingly, this volume will be of interest to researchers and clinicians alike. |