| Design & Developement of Floating Tablet of Tolperisone Hydrochloride Contributor(s): Soni, Ravi (Author), Patel, Mukesh (Author), Patel, Natvarlal (Author) |
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ISBN: 3659136069 ISBN-13: 9783659136061 Publisher: LAP Lambert Academic Publishing OUR PRICE: $69.77 Product Type: Paperback Published: May 2012 |
| Additional Information |
| BISAC Categories: - Medical | Pharmacology |
| Physical Information: 0.37" H x 6" W x 9" (0.54 lbs) 160 pages |
| Descriptions, Reviews, Etc. |
| Publisher Description: Tolperisone hydrochloride has a short elimination half- life and rapidly absorbed from gastrointestinal tract.2 If it is formulated by conventional tablets, it will require multiple daily administrations (2-3 times daily) which ultimately results into in conveniency to the patients and possibility of reduced compliance with prescribed therapy. Tolperisone HCl is more stable in acidic medium (pH > 4.5), and in alkaline medium (pH 4 to 7) tolperisone breaks down into 4-MMPPO and piperidine. Thus, the patient is exposed to an uncontrollable quantity of 4-MMPPO 2methyl-1-(4methylphenyl)-propanone]. Proposed are floating tolperisone tablets with the controlled release of the active substance tolperisone in the stomach at pH 1 to 2. |
