| Zlokachestvennye Zabolevaniya Krovi Contributor(s): Gra Ol'ga (Author) |
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ISBN: 3843312435 ISBN-13: 9783843312431 Publisher: LAP Lambert Academic Publishing OUR PRICE: $69.77 Product Type: Paperback Language: Russian Published: January 2011 |
| Additional Information |
| BISAC Categories: - Science | Life Sciences - Biology |
| Physical Information: 0.41" H x 6" W x 9" (0.59 lbs) 176 pages |
| Descriptions, Reviews, Etc. |
| Publisher Description: Monografiya posvyashchena izucheniyu mekhanizmov razvitiya i progressii onkogematologicheskikh zabolevaniy s pomoshch'yu biochipovykh tekhnologiy. V monografii privoditsya ischerpyvayushchiy literaturnyy obzor, v kotorom podrobno okharakterizovany vse klyuchevye geny sistemy metabolizma ksenobiotikov i lekarstvennykh preparatov, polimorfizm v kotorykh mozhet modulirovat' risk razvitiya razlichnykh mnogofaktornykh zabolevaniy, v tom chisle zlokachestvennykh zabolevaniy krovi. Dlya analiza polimorfizma v genakh-kandidatakh razvitiya onkogematologicheskikh zabolevaniy v rabote skonstruirovan biologicheskiy mikrochip, pozvolyayushchiy provodit' odnovremennyy analiz 16 odnonukleotidnykh zamen i 2 deletsiy v 10 genakh sistemy biotransformatsii. S pomoshch'yu razrabotannogo biochipa provedena otsenka geneticheskikh faktorov predraspolozhennosti, prognoza i effektivnosti lecheniya bol'nykh zlokachestvennymi zabolevaniyami krovi, na osnove kotoroy opredeleny genotipy i alleli vysokogo riska razvitiya i progressii leykozov i limfom v detskom i vzroslom vozraste. Pokazana vozmozhnost' primeneniya razrabotannogo biochipa dlya dal'neyshikh issledovatel'skikh tseley i klinicheskoy praktiki. |