| Vliyanie Salitsilata Na Tsikl Krebsa Mitokhondrii Contributor(s): Mogilevskaya Ekaterina (Author) |
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ISBN: 3659241784 ISBN-13: 9783659241789 Publisher: LAP Lambert Academic Publishing OUR PRICE: $50.27 Product Type: Paperback Language: Russian Published: October 2012 |
| Additional Information |
| BISAC Categories: - Science | Life Sciences - Biochemistry |
| Physical Information: 0.25" H x 6" W x 9" (0.36 lbs) 104 pages |
| Descriptions, Reviews, Etc. |
| Publisher Description: Salitsilaty (v t.ch. aspirin) otnosyatsya k gruppe nesteroidnykh protivovospalitel'nykh sredstv. Pobochnye effekty salitsilatov mozhno razdelit' na tri gruppy: 1) Effekty, voznikayushchie v rezul'tate snizheniya biosinteza prostaglandinov: ul'tserogennoe deystvie na zheludochno-kishechnyy trakt; povrezhdenie pochek; povyshenie arterial'nogo davleniya; 2) Toksicheskie effekty: gepato- i gematoksichnost'; 3) allergicheskie reaktsii. V to vremya kak mekhanizmy vozniknoveniya pobochnykh effektov pervoy i tret'ey grupp dostatochno khorosho izucheny, izmeneniya v kletke, razvivayushchiesya pri toksicheskikh vozdeystviyakh, v chastnosti, na pechen', ostayutsya ne do kontsa vyyasnennymi. Kak pravilo, lekarstva imeyut mnozhestvennye effekty na vnutrikletochnyy metabolizm. Problema vyyavleniya glavnykh i vtorostepennykh mekhanizmov toksicheskogo deystviya lekarstv ne mozhet byt' reshena tol'ko eksperimental'no, t. k. analiz razlichnykh vliyaniy trebuet ikh izbiratel'nogo vyklyucheniya, chto obychno nevozmozhno sdelat' v eksperimente. S pomoshch'yu predstavlennoy modeli segmenta tsikla Krebsa mitokhondrii, funktsioniruyushchey pri povyshennom energopotreblenii, izucheny effekty salitsilata na tsentral'nyy metabolizm gepatotsita. |