| Adenosine's Role in Controlling Cmro2 Following Hypoxia-Ischemia Contributor(s): Ridha Mustafa (Author) |
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ISBN: 365934818X ISBN-13: 9783659348181 Publisher: LAP Lambert Academic Publishing OUR PRICE: $50.27 Product Type: Paperback Published: February 2013 |
| Additional Information |
| BISAC Categories: - Medical | Clinical Medicine |
| Physical Information: 0.19" H x 6" W x 9" (0.28 lbs) 80 pages |
| Descriptions, Reviews, Etc. |
| Publisher Description: The cerebral metabolic rate of oxygen (CMRO2) has been shown to be an early indicator of hypoxia-ischemia (HI); however, the mechanisms controlling post-HI CMRO2 are not clear. One potential mechanism is the activation of the adenosine A1 receptor due to increased adenosine concentrations during the insult. The present study investigated if the specific adenosine A1 antagonist, DPCPX, would reduce the typical reduction in CMRO2 and electrical cortical activity following HI. Measurements of CMRO2 and electrical cortical activity were obtained on piglets by near-infrared spectroscopy (NIRS) and amplitude-integrated electroencephalography (aEEG), respectively. The post-HI measurements of CMRO2 and mean aEEG background voltage were significantly less depressed in piglets treated with DPCPX than controls (p |